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CURRENT FREQUENCY AND ETIOLOGY OF MELAS SYNDROME

Abstract

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) condition is an interesting hereditary mitochondrial problem that influences the body's capacity to deliver energy. This article will look at the ongoing comprehension of the recurrence of melas disorder and investigate the hereditary causes and etiology of this condition.

Keywords

Syndromes, signs, diseases, investigation, MELAS, determinations, levels, potential treatments.

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References

  1. Sinnecker T, Andelova M, Mayr M, Rüegg S, Sinnreich M, Hench J, Frank S, Schaller A, Stippich C, Wuerfel J, Bonati LH. Diagnosis of adult-onset MELAS syndrome in a 63-year-old patient with suspected recurrent strokes - a case report. BMC Neurol. 2019 May 08;19(1):91.
  2. Bhatia KD, Krishnan P, Kortman H, Klostranec J, Krings T. Acute Cortical Lesions in MELAS Syndrome: Anatomic Distribution, Symmetry, and Evolution. AJNR Am J Neuroradiol. 2020 Jan;41(1):167-173.
  3. El-Hattab AW, Adesina AM, Jones J, Scaglia F. MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab. 2015 Sep-Oct;116(1-2):4-12.
  4. Molnár MJ, Valikovics A, Molnár S, Trón L, Diószeghy P, Mechler F, Gulyás B. Cerebral blood flow and glucose metabolism in mitochondrial disorders. Neurology. 2000 Aug 22;55(4):544-8.
  5. Iizuka T, Sakai F. Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms. Curr Neurovasc Res. 2005 Jan;2(1):29-45.
  6. Koga Y, Povalko N, Inoue E, Nakamura H, Ishii A, Suzuki Y, Yoneda M, Kanda F, Kubota M, Okada H, Fujii K. Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research. J Neurol. 2018 Dec;265(12):2861-2874.
  7. Li J, Zhang W, Cui Z, Li Z, Jiang T, Meng H. Epilepsy Associated With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes. Front Neurol. 2021;12:675816.
  8. Möller HE, Kurlemann G, Pützler M, Wiedermann D, Hilbich T, Fiedler B. Magnetic resonance spectroscopy in patients with MELAS. J Neurol Sci. 2005 Mar 15;229-230:131-9.
  9. Thambisetty M, Newman NJ. Diagnosis and management of MELAS. Expert Rev Mol Diagn. 2004 Sep;4(5):631-44.
  10. Radelfahr F, Klopstock T. [Diagnostic and Therapeutic Approaches for Mitochondrial Diseases]. Fortschr Neurol Psychiatr. 2018 Sep;86(9):584-591.

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