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Vol. 11 No. 04 (2024)
International Multidisciplinary Journal for Research & Development (IMJRD)

Articles

EFFECTS OF SOME DRUGS ON FREE RADICAL PROCESSES IN THE GASTRIC MUCOSA IN A MODEL OF GASTROPATHY IN RATS

Published 2024-04-13

  • 1,2Djanaev G.Yu., 1,2Mustanov T.B., 1,2Mamadjanova M.A., 1Kakhkharova SH.B.

1,2Djanaev G.Yu., 1,2Mustanov T.B., 1,2Mamadjanova M.A., 1Kakhkharova SH.B.
Tashkent Medical Academy, Department of Pharmacology, Tashkent, Uzbekistan Alfraganus University, Tashkent, Uzbekistan

Abstract

In gastropathy developed under the influence of indomethacin in the gastric mucosa, the effect of some pharmacological agents on the amount of acylhydroperakis and malondialdehyde and the activity of catalase and superoxide dismutase enzymes was studied. All of the used drugs have been found to have a similar effect on the peroxidation of fats and the activity of enzymes of the antioxidant system. Lesboxol, a combination of plant extracts, has been proven to be more active than Mucogen (rebamipid) and Misoprostol.

Keywords

Gastropathy, indomethacin, fat peroxidation, antioxidant system, gastroprotector.

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References

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