SECONDARY AND TERTIARY HYPERPARATHYROIDSIS IN CHRONIC KIDNEY DISEASE

Authors

Abdukhalilov Farrukh Shukhratjon ugli,Yuldasheva Nodira Ergashevna Andijan state medical institute

Keywords:

Clinical case; secondary hyperparathyroidism; tertiary hyperparathyroidism; cinacalcet; parathyroidectomy; hemodialysis; kidney transplant.

Abstract

Treatment goals for secondary hyperparathyroidism in patients with chronic kidney disease are aimed at preventing disease progression and suppressing parathyroid activity through modulation of vitamin D receptors and calcium-sensing receptors. However, treatment options are limited in severe hyperparathyroidism; monoclonal changes and nodular transformation of glands with loss of receptors for vitamin D and calcium form resistance to this therapy with the development of drug-uncontrolled hyperparathyroidism.

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References

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Chertow GM, Lu ZJ, Xu X, et al. Self-reported symptoms in patients on hemodialysis with moderate to severe secondary hyperparathyroidism receiving combined therapy with cinacalcet and low-dose vitamin D sterols. Hemodialysis International. 2012;16(2):188-197. doi: 10.1111/j.1542-4758.2011.00642.x.

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Published

2024-03-24

How to Cite

Abdukhalilov Farrukh Shukhratjon ugli,Yuldasheva Nodira Ergashevna. (2024). SECONDARY AND TERTIARY HYPERPARATHYROIDSIS IN CHRONIC KIDNEY DISEASE. International Multidisciplinary Journal for Research & Development, 11(03). Retrieved from https://www.ijmrd.in/index.php/imjrd/article/view/1207