DEVELOPMENT OF METABOLIC SYNDROME DEPENDING ON GENDER AND AGE

Abstract

Metabolic syndrome (MS) (synonyms: metabolic syndrome X, Reaven syndrome, insulin resistance syndrome) is an increase in visceral fat mass, a decrease in the sensitivity of peripheral tissues to insulin and hyperinsulinemia, which disrupt carbohydrate, lipid, purine metabolism, and also cause arterial hypertension. In 1981, M. Hanefeld and W. Leoonardt proposed to designate cases of a combination of various metabolic disorders with the term “metabolic syndrome” (MS). In 1988, Professor G. Reaven, in his Banting lecture, based on his own observations and generalization of research by other authors, put forward a hypothesis according to which insulin resistance, abdominal obesity, arterial hypertension (AH), atherogenic dyslipidemia and coronary heart disease (CHD) serve as a manifestation of a pathological condition, which he proposed to call “syndrome X”. In 1989 D.• insulin resistance with reduced carbohydrate tolerance and hyperinsulinemia;• dyslipoproteinemia with hypertriglyceridemia and reduced levels of high-density lipoprotein cholesterol;• tendency to thrombosis and increased plasma levels of plasminogen activator inhibitor;• arterial hypertension against the background of increased activity of the sympathetic nervous system;• generalized obesity with increased secretion of free fatty acids into the portal vein.