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Vol. 11 No. 06 (2024)
International Multidisciplinary Journal for Research & Development

Articles

CREATION OF AN EXPERIMENTAL MODEL OF SPECIFIC HYPOSENSITIZING IMMUNOTHERAPY USING INDUSTRIAL DUST ALLERGENS

Published 2024-06-17

  • Madumarova Makhfuza Maksimovna

Madumarova Makhfuza Maksimovna
Senior lecturer of the Departament of Pathological Physiology. Andijan State Medical Institute

Abstract

For the first time in Uzbekistan, the allergenic and antigenic properties of an extract from industrial dust of a cotton paper mill have been established. In an experiment on guinea pigs, the criteria for the allergenicity of the studied dust were identified: in the blood serum of sensitized animals, specific thermolabile homocytotropic antibodies were determined, active and passive skin sensitization, active and passive anaphylactic shock, and an allergic reaction of mast cell degranulation were successfully reproduced. The presence of a direct correlation between allergic reactions and the level of homocytotropic antibodies in the blood serum of sensitized animals has been proven.

Keywords

Allergen, sensitization, guinea pigs, homocytropic antibodies, immunotherapy.

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References

  1. Иванова Е.B., Богатырева 3.И., Исаева М.А., Сучкова Е.Н., и др. Антитериодные антитела различной специфичности в патогенезе и диагностике аутоимунных заболеваний щитовидной железы / Тер. архив.-2009.-Ne 10.-С. 39-45.
  2. Клиническая иммунология и аллергология; в 3-х томах / Под ред. Л. Йегера.-М.: Медицина, 1990.-Т.3.-528 с.
  3. Нугманова Д.С. Значение антиидиотопических антиIgE-аутоантител при атопических заболеваниях // Иммунология. - 1997.-Ne 1.-C. 14-18.
  4. Медведев И.Н. Экспериментальное моделирование гиперхолестерине мии и тромбоцитарных нарушений у кроликов / Кардиология.-2006.-No 3.-С. 46-54. 5. Рожкова Т.А., Кухарчук В.В., Титов В.Н., Яровая Е.Б., и др. Лечение пациентов с гипертриглицеридемией //Тер. архив. - 2007.- Ne 2 - C. 29-33.
  5. Mirzakarimova, D.B., Hodjimatova, G.M. and Abdukodirov, S.T., 2024. FEATURES OF PATHOGENESIS, CLINICAL PICTURE AND DIAGNOSIS OF CO-INFECTION OF THE LIVER WITH HEPATITIS B AND C VIRUSES. International Multidisciplinary Journal for Research & Development, 11(02).
  6. Taxirovich, A. S. (2023). The Main Etiological Factors, Methods of Prevention and Treatment of Meningitis. Inter-national Journal of Scientific Trends, 2(2), 141-148.
  7. Djurayev Muzaffar Gulamovich. (2023). CLASSIFICATION OF THE MOST COMMON INFECTIOUS DISEASES TODAY. International Multidisciplinary Journal for Research & Development, 10(10). Retrieved from https://www.ijmrd.in/index.php/imjrd/article/view/134
  8. Maksimovna, Y.R., 2024. STUDYING THE EMOTIONAL STATE IN IRRITABLE BOWEL SYNDROME. International journal of medical sciences, 4(05), pp.50-52.

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