STUDY OF BIOCHEMICAL AND IMMUNOLOGICAL FEATURES OF ANTIMICROBIAL PEPTIDES
Abstract
The oral cavity is the main gateway for infection to enter the human body. With inhaled air and food, a huge number of different microorganisms, including pathogens, are deposited on the mucous membrane. Most currently known AMPs have a broad spectrum of antimicrobial activity, acting against Gram-positive and Gram-negative bacteria, as well as yeast and some viruses. In addition, convincing evidence has been obtained that a number of AMPs have anticarcinogenic activity, as well as immunomodulators. The article examines in detail the biochemical and immunological features of antimicrobial peptides in the oral cavity. Due to the fact that oral AMPs are diverse and act on microorganisms very quickly, the likelihood of developing resistance to them is quite small. This gives hope that AMPs can be used to produce antimicrobials, resistance to which develops very slowly. Therefore, it is proposed to use AMPs with antiviral and antifungal activity in immunocompromised individuals, including AIDS patients, for the prevention and treatment of candidiasis and herpetic gingivostomatitis. The use of AMP for the prevention and treatment of gingivitis and periodontitis seems promising.
Keywords
AMP, mucous membrane, immunological and biochemical functions, α- and β-defensins, cathelicidins, salivary glands.
References
- Furci L, Sironi F, Tolazzi M, Vassena L, Lusso P. Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4. Blood. 2007;109(7):2928-2935. doi:10.1182/blood-2006-05-024489.
- Higazi AA, Ganz T, Karikoi K, Cines DB. Defensin modulates Tissue-type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells. Journal Biological Chemistry. 1996;271(30):17650-17655. doi:10.1074/jbc.271.30.17650.
- Van Wetering S, Tjabringa S, Hiemstra PS. Interaction between neurtophildelided antimicrobial peptides and airway epithelial cells. Journal of Leukocyte Biology. 2005;77(4):444-450. doi:10.1189/jlb.0604367.
- Puklo M, Guentsch A, Hiemstra PS, Eick S, Potempa J. Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin ll-37 in theinnate immune response against periodontogenic bacteria. Oral Microbiology and Immunology. 2008;23(4):328-335. doi:10.1111/j.1399-302x.2008.00433.x.
- Nozimjon O’g’li, S. S., & Maksimovna, M. M. (2022). THE ORIGIN OF MIASTHENIA DISEASE AND METHODS USED IN TREATMENT. Conferencea, 31-33.
- Nozimjon O’g’li, S. S., & Kasimjanovna, D. O. (2022, November). ORIGIN, PREVENTION OF MENINGITIS DISEASE, WAYS OF TRANSMISSION AND THE USE OF DIFFERENT ROUTES IN TREATMENT. In E Conference Zone (pp. 37-40).
- Nozimjon O’g’li, S. S. (2022). CAUSES OF THE ORIGIN OF OSTEOCHONDROSIS, SYMPTOMS, DIAGNOSIS AND TREATMENT METHODS. Conferencea, 76-77.
- Nozimjon o’g’li, S. S. (2022). INFORMATION ABOUT THE STRUCTURE OF THE MEMBRANE OF EPITHELIAL TISSUE AND GLANDS. British Journal of Global Ecology and Sustainable Development, 10, 65-69.
- Nozimjon o’g’li, S. S. (2022). First Aid Medication and Remedies for Heart Failure. Academia Open, 7, 10-21070.
- Nozimjon o’g’li, S. S., & Xasanboy o’g’li, A. A. (2021). Quantitative Indicators of Villi Cells in the Intraepithelial Part of the Small Intestine. EUROPEAN JOURNAL OF INNOVATION IN NONFORMAL EDUCATION, 1(2), 19-21.
- Mavlonovna RD. Factors That Increase the Activity of Women and Girls in Socio-political Processes at a New Stage of Development of Uzbekistan. JournalNX.;7(07):61-6.
- Mavlonovna, R. D. Participation of Uzbek Women in Socio-economical and Spiritual Life of the Country (on the Examples of Bukhara and Navoi Regions). International Journal on Integrated Education, 4(6), 16-21.
- Mavlonovna, R. D. (2021, May). PARTICIPATION OF WOMEN IN EDUCATION AND SCIENCE. In E-Conference Globe (pp. 158-163).
- Mavlonovna, R. D., & Akbarovna, M. V. (2021, July). PROVISION OF FAMILY STABILITY AS A PRIORITY OF STATE POLICY. In Archive of Conferences (pp. 34-39).