IMMUNE DISORDERS IN COMMUNITY-ACQUIRED PNEUMONIA AND THEIR INFLUENCE ON THE SEVERITY OF THE DISEASE
Abstract
Humoral and cellular immunity factors: blood content of T-lymphocytes and their subpopulations, B-lymphocytes, circulating immune complexes, determination of neutrophilic phagocytosis activity, cytokine system - IL-2, -4, -6, -8; TNFα in the dynamics of the disease provide information on the state of the immune system. Disorders in the immune system that determine the severity of pneumonia and the volume of inflammatory damage to the lung tissue have been identified. Insufficiency of phagocytic protection and impaired elimination of immune complexes, decreased activity of T-effector cells against the background of an increased reaction of natural killers, deficiency of humoral factors in the form of a decrease in the level of B-lymphocytes and a tendency to decrease in immunoglobulins M and G cause severe course of community-acquired pneumonia and lobar lung damage. The indicated disturbances in the immune system are reliably associated with an imbalance of cytokines, with the predominance of their proinflammatory activity and a decrease in regulatory functions, and require the development of immunomodulatory therapy.
Keywords
community-acquired pneumonia, pathogenesis, immune system, cytokines, immunocorrective system.
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