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Vol. 10 No. 10 (2023)
Volume 10 Issue 10

Articles

SOME ASPECTS OF APOPTOSIS AND INFECTIOUS DISEASES

Published 2023-11-04

  • Solomonnik Oksana Nikolaevna

Solomonnik Oksana Nikolaevna
Department of infectious diseases Andijan State Medical Institute Uzbekistan, Andijan

Abstract

Apoptosis, as an immunomodulatory form of cell death, plays a stabilizing role in maintaining the optimal number of cells in the body. The biological essence of cell death in infectious pathology is not sufficiently illuminated, and the concept of the negative and positive significance of apoptosis in the pathogenesis of diseases is presented ambiguously. The review focuses on the classical caspase-dependent apoptosis of innate and adaptive immune cells, the reactivity of which is associated with the initiation and outcome of infectious processes. A number of pathogens of bacterial and viral infections are capable of being triggers or inhibitors of apoptosis in the eukaryotic host cell, avoiding the action of immune system factors.

Keywords

Apoptosis, neutrophils, immune system, infectious diseases, macrophages, lymphocytes.

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