THE VALUE OF KLOTHO PROTEIN IN THE ASSESSMENT OF RENAL DYSFUNCTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE COMORBID WITH DIABETES
Abstract
This article explores the role of the Klotho protein in assessing renal dysfunction in patients with chronic obstructive pulmonary disease (COPD) comorbid with diabetes mellitus (DM). Klotho, a critical anti-aging protein, is primarily expressed in the kidneys and serves as a biomarker for early renal impairment. The study highlights how reduced Klotho levels correlate with oxidative stress, inflammation, and renal fibrosis in COPD and DM patients, emphasizing its potential as a diagnostic and therapeutic target. The article also discusses clinical implications and challenges in integrating Klotho protein assessment into routine medical practice.
Keywords
Klotho protein, renal dysfunction, chronic obstructive pulmonary disease, diabetes mellitus, biomarkers, oxidative stress, inflammation, renal fibrosis, early diagnosis, therapeutic target.
References
- Hu, M. C., & Kuro-o, M. (2019). The Klotho protein and its emerging role in kidney disease. Kidney International, 95(5), 1111–1122.
- Nigwekar, S. U., et al. (2014). Role of Klotho in mineral and bone disorders. Current Opinion in Nephrology and Hypertension, 23(4), 377–385.
- Chen, T. H., et al. (2021). Reduced serum Klotho levels are associated with the progression of chronic kidney disease. Nephrology Dialysis Transplantation, 36(1), 101–110.
- GBD Chronic Respiratory Disease Collaborators. (2020). Global burden of COPD and related mortality trends. The Lancet, 6(8), 563–571.