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CHEMICAL-TOXICOLOGICAL ANALYSIS OF ALCOHOL POISONING USING A GAS CHROMATOGRAPH (CRYSTALLUX-4000M)

Abstract

 This article presents a modern methodological approach to the chemical-toxicological assessment of alcohol poisoning through the use of gas chromatography, with a focus on the CrystalLux-4000M system. Given the high incidence of acute ethanol intoxication in both forensic and clinical practice, the need for accurate, reproducible, and legally defensible methods for ethanol detection in biological samples is paramount. The article describes in detail the principles of headspace gas chromatography, sample preparation procedures, calibration methods, and forensic interpretation of ethanol concentrations in blood, urine, and vitreous humor. The analytical reliability and sensitivity of the CrystalLux-4000M platform are evaluated in relation to its role in toxicological diagnostics and medicolegal investigations.

Keywords

Alcohol poisoning, ethanol, gas chromatography, CrystalLux-4000M, forensic toxicology, blood alcohol concentration.

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References

  1. Jones, A. W. (2010). Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework. Forensic Science International, 200(1-3), 1–20.
  2. Karch, S. B. (2015). Drug Abuse Handbook (3rd ed.). CRC Press.
  3. Oreskovich, M. R., et al. (2021). Interpretation of ethanol levels in postmortem specimens. Journal of Analytical Toxicology, 45(2), 123–130.
  4. Manufacturer’s Manual. CrystalLux-4000M: Chromatographic Solutions for Toxicology. Chromatek, 2020.

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