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CAUSES OF DRUG-RESISTANT TUBERCULOSIS IN FERGANA REGION

Abstract

This article provides an in-depth analysis of the key causes leading to the emergence of drug-resistant (MDR – multidrug-resistant) tuberculosis (TB) in the Fergana region. It presents statistical data and detailed district-level breakdowns illustrating the wide spread of the disease. Medical, socioeconomic, and migration-related factors contributing to the development of drug resistance are highlighted separately [1][2]. The paper also develops recommendations based on observed treatment non-compliance, self-medication practices, delayed healthcare seeking, and structural issues in the health system [3][5]. These recommendations aim to increase public awareness, strengthen psychological and social support, introduce electronic monitoring, and enhance preventive measures.

Keywords

tuberculosis, TB, drug resistance, MDR, delayed diagnosis, incorrect treatment, treatment compliance, migration, poverty, socioeconomic factors, pharmacotherapy, TB prevention.

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References

  1. Ministry of Health of the Republic of Uzbekistan. “2023 Tuberculosis Report.” Tashkent, 2024.
  2. World Health Organization. Global Tuberculosis Report, 2023. Geneva: WHO.
  3. Fergana Regional Health Department. “Regional Epidemiological Data.” Fergana, 2023.
  4. Medical Academic Literature: Phthisiology. Textbook. Tashkent Medical Publishing, 2022.
  5. Karimov K., Ismoilova Sh. “Problems of Drug Resistance in Tuberculosis.” Tashkent, 2021.
  6. WHO. Companion Handbook to the WHO Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis. Geneva, 2014.
  7. Yuldashev A., Mahmudova D. “Analytical Data on Drug-Resistant TB in Uzbek Regions.” Medical Journal, 2023(2): 45–52.
  8. WHO Europe. “Action Plan for the Prevention and Control of M/XDR-TB in the WHO European Region 2011–2015.” Copenhagen, 2011.
  9. Aziz M.A., Wright A., Laserson K., et al. “Epidemiology of Anti-TB Drug Resistance.” The Lancet, 2006; 368(9553): 2142–2154.
  10. Dara M., Acosta C.D., Melchers N.V.S., et al. “TB Control in Prisons: Current Status and Research Gaps.” Int J Infect Dis, 2015; 32: 111–117.

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