PATHOMORPHOLOGICAL ASPECTS OF PLACENTERAL CIRCULATION DISORDERS
Abstract
The review systematized the macro- and micromorphological signs of chronic placental insufficiency: immaturity of the villous tree, fibrinoid deposits, obliteration of arterioles, and reduction of the capillary network. The immunohistochemical profile (decreased CD31/CD34 expression, increased VEGF and CD95) reflects endothelial damage, compensatory angiogenesis, and increased apoptosis. The severity of these changes correlates with fetal hypoxia levels and the risk of adverse perinatal outcomes. The purpose of the review is to summarize the morphological and immunohistochemical markers of CKD and their prognostic significance for obstetric practice.
Keywords
chronic placental insufficiency; villous tree; fibrinoid; CD31; CD34; VEGF; CD95; apoptosis; fetal hypoxia.
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