MORPHOGENESIS OF SUDDEN CARDIAC DEATH IN HYPERANDROGENEMIA ON AN EXPERIMENTAL MODEL
Abstract
The work summarizes literature data on the effect of testosterone and its synthetic derivatives on the body of athletes. The biosynthesis and metabolism pathways of testosterone, the testosterone signaling pathway, and its main biological effects are characterized. The main attention is paid to the problems of hypo- and hyperandrogenemia, as two extreme manifestations of deviation from the physiological level of testosterone in the blood in men. In this regard, prospects for further research were identified: the effect of hyperandrogenemia on the cardiac muscle in athletes and men using natural and synthetic testosterone analogues as means of increasing physical endurance and activity.
Keywords
Sudden cardiac death,anabolic steroids,athletes, hyperestrogenemia, cardiomyocytes.
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