RENAL PATHOMORPHOLOGICAL CHANGES IN PATIENTS WITH ISCHEMIC STROKE

Abstract

To study pathomorphological changes occurring in renal tissue of patients with ischemic stroke and assess their clinical significance.

Materials and Methods: The study was conducted on 156 patients diagnosed with ischemic stroke. Renal function parameters (creatinine, urea, glomerular filtration rate) were evaluated. For morphological examination, renal biopsy materials were studied using light and electron microscopy methods.

Results: Ischemic and degenerative changes, tubulointerstitial damage, and signs of glomerular sclerosis were identified in the kidneys of patients who experienced ischemic stroke. The severity of renal dysfunction was correlated with the degree of cerebral ischemia and stroke volume.

Conclusion: Ischemic stroke leads to specific pathomorphological changes in renal tissue and causes the development of cerebro-renal syndrome similar to cardiorenal syndrome.

Keywords: ischemic stroke, renal pathomorphology, cerebro-renal syndrome, glomerular filtration, tubulointerstitial damage

Introduction. Ischemic stroke is one of the pressing problems of modern medicine, characterized by high rates of disability and mortality. According to the World Health Organization, 15 million people worldwide experience stroke annually. Ischemic stroke causes serious pathomorphological changes not only in the central nervous system but also in several organs, particularly the kidneys.

The interaction between the brain and kidneys - cerebro-renal syndrome - has gained considerable attention in recent years. However, morphological changes occurring in the kidneys as a result of ischemic stroke have not been sufficiently studied. This problem is particularly significant in the management of severe stroke and its complications.