THE ROLE OF APOLIPOPROTEINS IN CHOLESTEROL METABOLISM, OBESITY MECHANISMS, AND SPHINGOLIPIDOSES
Abstract
This review article comprehensively covers three important aspects of lipid metabolism: the role of apolipoproteins in cholesterol transport, adipose tissue physiology and obesity mechanisms, and the group of hereditary diseases known as sphingolipidoses. The article analyzes the molecular mechanisms, pathogenesis, and treatment methods of these processes based on modern biochemical and clinical data. Disorders of lipid metabolism represent one of the most pressing problems in contemporary medicine, playing a crucial role in the development of cardiovascular diseases, metabolic syndrome, and hereditary lysosomal storage diseases.
Keywords
apolipoproteins, lipoproteins, cholesterol transport, adipose tissue, obesity, adipokines, sphingolipidoses, lysosomes, metabolic diseases
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