DEVELOPMENT OF TITRIMETRIC METHODS FOR THE QUANTITATIVE DETERMINATION OF LEVOCARNITINE IN AQUEOUS SOLUTIONS
Abstract
This study is devoted to the development and analytical substantiation of titrimetric methods for the quantitative determination of levocarnitine in aqueous solutions. Due to nature of levocarnitine, direct acid–base titration in aqueous media is associated with difficulties in achieving a distinct equivalence point. Therefore, non-aqueous titration, potentiometric endpoint detection, and back titration approaches were investigated. The developed methods were evaluated in terms of accuracy, precision, and specificity. The obtained results demonstrate that titrimetric methods can be effectively applied for the quality control of levocarnitine pharmaceutical preparations
Keywords
levocarnitine, titrimetric analysis, non-aqueous titration, potentiometric method, quantitative determination, aqueous solution.
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