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Vol. 12 No. 12 (2025)
International Multidisciplinary Journal for Research & Development

Articles

SEQUESTRATION AND TOXICOLOGICAL ASSESSMENT OF EMERGING PHARMACEUTICAL CONTAMINANTS USING FUNCTIONALIZED BIOPOLYMER-BASED ADSORBENTS

Published 2025-12-27

  • Xusanboyeva Zumrad Rustamovna

Xusanboyeva Zumrad Rustamovna
Sineor lecturer at pharmaceutical department at Andijane State Medical Institute

Abstract

The continuous release of pharmaceutical residues into aquatic environments has emerged as a global environmental and public health concern. Non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, antiepileptics, and β-blockers are frequently detected in surface water, groundwater, and treated wastewater, where they exert toxic effects on aquatic organisms and may pose long-term risks to human health. This study presents a comprehensive assessment of the sequestration of multiple pharmaceutical contaminants—ibuprofen, diclofenac, paracetamol, carbamazepine, and ciprofloxacin—using functionalized biopolymer-based adsorbents. Emphasis is placed on adsorption mechanisms, removal efficiency, and the reduction of toxicological impacts on biological systems. Toxicity evaluation before and after adsorption demonstrates a significant decrease in acute and chronic toxic effects, highlighting the potential of advanced biopolymer composites as sustainable materials for pharmaceutical wastewater treatment.

Keywords

Emerging contaminants; Pharmaceutical pollutants; Toxicology; Adsorption; Biopolymers; Environmental safety

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References

  1. Pazliddinov, A., and A. Shokirov. "ANALYZING COLLECTED DATABASE BY USING GOOGLE FORMS TO DETECT AN INCREASE IN THE NUMBER OF FUNGAL INFECTIONS AMONG CHILDREN POST-COVID-19 PERIOD." Экономика и социум 3-1 (106) (2023): 176-181.
  2. Pazliddinov, A. V. "ADDICTION IS THE PLAGUE OF THE CENTURY." Экономика и социум 12-2 (103) (2022): 120-122.
  3. Jasurbek, A. P. X. (2024). HIGH-GRADE ASTROCYTOMA TREATMENT: EFFICACY OF ZOTIRACICLIB AND TEMOZOLOMIDE COMBINATION THERAPY IN A PHASE I CLINICAL TRIAL. Journal of Modern Educational Achievements, 10(10), 55-68.
  4. Voxobjon o‘g‘li, Pazliddinov Abdulvohid. "High-Performance Liquid Chromatography (HPLC) in the Analysis of Injectable Pharmaceutical Forms: Applications and Advantages." Journal of Modern Educational Achievements 5.5 (2025): 18-22.
  5. Jasurbek, Abdulvohid Pazliddinov Xolmatov. "HIGH-GRADE ASTROCYTOMA TREATMENT: EFFICACY OF ZOTIRACICLIB AND TEMOZOLOMIDE COMBINATION THERAPY IN A PHASE I CLINICAL TRIAL." Journal of Modern Educational Achievements 10.10 (2024): 55-68.
  6. Tojiddinova, M. "HIGH RISKS OF ANTIBOTIC RESISTANCE AFTER COVID-19 IN UZBEKISTAN." Экономика и социум 3-2 (106) (2023): 302-303.
  7. Ko‘paysinovna, Ziyayeva Muazzam. "Application of High-Performance Liquid Chromatography (HPLC) in the Analysis of Pharmaceutical Drugs." Journal of Modern Educational Achievements 5.5 (2025): 53-59.
  8. Daughton, C.G. and Ternes, T.A. (1999) ‘Pharmaceuticals and personal care products in the environment: Agents of subtle change?’, Environmental Health Perspectives, 107(Suppl 6), pp. 907–938. https://doi.org/10.1289/ehp.99107s6907
  9. Kümmerer, K. (2009) ‘Antibiotics in the aquatic environment – A review – Part I’, Chemosphere, 75(4), pp. 417–434. https://doi.org/10.1016/j.chemosphere.2008.11.086
  10. Luo, Y., Guo, W., Ngo, H.H., Nghiem, L.D., Hai, F.I., Zhang, J., Liang, S. and Wang, X.C. (2014) ‘A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment’, Science of the Total Environment, 473–474, pp. 619–641. https://doi.org/10.1016/j.scitotenv.2013.12.065
  11. Snyder, S.A., Westerhoff, P., Yoon, Y. and Sedlak, D.L. (2003) ‘Pharmaceuticals, personal care products, and endocrine disruptors in water: Implications for the water industry’, Environmental Engineering Science, 20(5), pp. 449–469. https://doi.org/10.1089/109287503768335931
  12. Klavarioti, M., Mantzavinos, D. and Kassinos, D. (2009) ‘Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes’, Environment International, 35(2), pp. 402–417. https://doi.org/10.1016/j.envint.2008.07.009
  13. Crini, G. and Lichtfouse, E. (2019) ‘Advantages and disadvantages of techniques used for wastewater treatment’, Environmental Chemistry Letters, 17(1), pp. 145–155. https://doi.org/10.1007/s10311-018-0785-9

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