INFLUENCE OF MUMIYO EXTRACT ON PLATELET-MEDIATED HEMOSTASIS IN DOGS
Keywords:
Alai mumiyo, mumiyo extract, platelets, platelet count, anticoagulant effect, hemostasis, dogs.Abstract
Platelets play a key role in primary hemostasis and blood coagulation. The present study investigated the effect of mumiyo extract on platelet count in dogs in order to clarify its contribution to the anticoagulant mechanism of this substance. Clinically healthy dogs were administered mumiyo extract orally at doses of 10, 25, and 50 mg/kg body weight. Platelet counts were determined before administration and at 1 and 2 hours after dosing. The results suggest that reduction of platelet number contributes to the anticoagulant action of mumiyo by affecting platelet-mediated hemostasis. Modulation of platelet count may therefore represent an important mechanism underlying the hypocoagulant effects of mumiyo.
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References
Qi Z, Kelley E. The WHO Traditional Medicine Strategy 2014-2023: A perspective. Science. 2014;346:S5-S6.
“WHO Traditional Medicine Strategy 2014-2023”. World Health Organization Retrieved 2014-04-20. 2013.
Shahriari M, Zare F, Nimrouzi M. The Curative Role of Bitumen in Traditional Persian Medicine. Acta Med Hist Adriat. 2018;16(2):283-92.
Olivieri MF, Marzari F, Kesel AJ, Bonalume L, Saettini F. Pharmacology and psychiatry at the origins of Greek medicine: The myth of Melampus and the madness of the Proetides. J Hist Neurosci. 2017;26(2):193-215.
Shirbeigi L ZA, Naghizadeh A, Alizadeh Vaghasloo M. The Concept of Temperaments in Traditional Persian Medicine. Trad Integr Med. 2017;2(3):143-56.
Frolova N, Kiseleva L, Tatiana. Chemical composition of mumijo and methods for determining its authenticity and quality (a review). Pharma Chem J. 1996;30(8):543-7.
Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK. Shilajit: a review. Phytother Res. 2007;21(5):401-5.
Verma A, Kumar N, Gupta L, Chaudhary S. Shilajitin Cancer Treatment: Probable Mode of Action. Int J Pharmaceutic Bio Arch. 2016;7(1):12-6.
Stohs SJ, Singh K, Das A, Roy S, Sen CK. 12-Energy and Health Benefits of Shilajit. In: Bagchi D, editor. Sustained Energy for Enhanced Human Functions and Activity. Academic Press; 2017. p. 187-204
Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. The need for formulation of Shilajit by its isolated active constituents. Phytother Res. 1991;5(5):211-6
Trivedi N, Mazumdar B, Bhatt J, Hemavathi K. Effect of shilajit on blood glucose and lipid profile in alloxaninduced diabetic rats. Indian J Pharmacol. 2004;36(6):373-6.
Загрутдинов, Ф. Ф., Мамадалиев, Ш. И., & Болтабоева, Д. Ф. (2024). Влияние Среднеазиатских Видов Мумиё на диурез и натрий урез у Крыс. Open Herald: Periodical of Methodical Research, 2(5), 12-14.
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