INFLAMMATION: MORPHOLOGICAL FEATURES AND CLINICAL SIGNIFICANCE
Keywords:
inflammation, pathological anatomy, histopathology, acute inflammation, chronic inflammation, biomarkers, artificial intelligenceAbstract
Inflammation is a central process in pathological anatomy, representing the body’s response to injury, infection, or immune dysregulation. While protective in nature, inflammation can also contribute to tissue damage and chronic disease progression. This article reviews the classical signs of inflammation, morphological features distinguishing acute and chronic forms, and their clinical implications. Special emphasis is placed on histopathological variants, the molecular basis of inflammatory responses, and emerging technologies such as artificial intelligence in digital pathology. Understanding inflammation at both structural and molecular levels is essential for advancing diagnostic accuracy and therapeutic strategies.Downloads
References
Kumar, V., Abbas, A. K., & Aster, J. C. (2021). Robbins and Cotran Pathologic Basis of Disease (10th ed.). Elsevier.
Nathan, C. (2002). Points of control in inflammation. Nature, 420(6917), 846–852.
Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature, 454(7203), 428–435.
Balkwill, F., & Mantovani, A. (2001). Inflammation and cancer: Back to Virchow? The Lancet, 357(9255), 539–545.
Ferrero-Miliani, L., Nielsen, O. H., Andersen, P. S., & Girardin, S. E. (2007). Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1β generation. Clinical and Experimental Immunology, 147(2), 227–235.
Coussens, L. M., & Werb, Z. (2002). Inflammation and cancer. Nature, 420(6917), 860–867.
Libby, P. (2002). Inflammation in atherosclerosis. Nature, 420(6917), 868–874.
Rock, K. L., & Kono, H. (2008). The inflammatory response to cell death. Annual Review of Pathology, 3, 99–126.
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