СANCER THERAPY-RELATED CARDIOTOXICITY :EARLY DETECTION USING LOW-CJST CLINICAL TOOLS- A CLINICALLY ORIENTED NARRATIVE ANALYSIS

Abstract

Cardiotoxicity remains one of the most consequential non-oncologic complications of modern cancer therapy, often limiting optimal treatment and compromising long-term survival. While advanced imaging modalities such as global longitudinal strain (GLS) and cardiac MRI have improved early detection, their limited availability in low-resource settings necessitates alternative strategies. This paper presents a clinically grounded, pathophysiology-driven framework for early detection of cardiotoxicity using widely accessible tools. Through retrospective case-based analysis and integration of mechanistic insights, we demonstrate that careful interpretation of symptoms, electrocardiography, basic echocardiography, and simple biomarkers can identify early myocardial injury before overt dysfunction develops. Practical diagnostic algorithms and cardioprotective strategies are proposed to support clinicians working in resource-constrained environments.