Skip to main navigation menu Skip to main content Skip to site footer

FEATURES OF COAGULATION HEMOSTASIS DISORDERS IN PREGNANT WOMEN: A SYSTEMATIC REVIEW OF CURRENT CONCEPTS AND CLINICAL SIGNIFICANCE

Abstract

Disorders of the hemostasis system in pregnant women represent a complex problem of modern perinatology. Physiological adaptive changes in coagulation often mask the development of severe pathologies, which complicates timely diagnosis.

Keywords

reproductive health, pregnancy, coagulation hemostasis, trimester-specific intervals, venous thromboembolism, DIC syndrome, Erez scale, intrahepatic cholestasis of pregnancy.

PDF

References

  1. Trends in Maternal Mortality 2000 to 2020: estimates by WHO, UNICEF, UNFPA, World Bank Group and UNDESA/Population Division. Geneva: World Health Organization; 2023.
  2. Arslanoğlu T, Kurt Bilirer K, Demirkıran Cİ, Ceylan Y, Veliyeva S, Koç İN, Polat İ. Intrahepatic cholestasis of pregnancy and coagulation: a dual risk of hypercoagulability and bleeding. BMC Pregnancy and Childbirth. 2025;25:498.
  3. Zaynutdinova D.L., Mirazizova N.M. Features of coagulation hemostasis disorders in pregnant women: current concepts and clinical significance. International Journal of Medical Sciences. 2025;5(11):180-182.
  4. Yang Y, Hu Y, Wu M, Xiang Z. Changes of new coagulation markers in healthy pregnant women and establishment of reference intervals in Changsha. Journal of Central South University (Medical Science). 2022;47(4):469-478.
  5. Sha M, Chen S. Pregnancy-related venous thromboembolism in Wuhan, China 2010-2022: A case-control study. Journal of Obstetrics and Gynaecology Research. 2023;49:1532-1538.
  6. Erez O, Othman M, Rabinovich A, Leron E, Gotsch F, Thachil J. DIC in Pregnancy - Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments. Journal of Blood Medicine. 2022;13:21-44.
  7. Wang W, Long K, Deng F, Ye W, Zhang P, Chen X, Dong W, Zheng P, Zhang X, Yang T, Chen W, Yang K. Changes in levels of coagulation parameters in different trimesters among Chinese pregnant women. Journal of Clinical Laboratory Analysis. 2021;35:e23724.
  8. Erez O, Novack L, Beer-Weisel R, Dukler D, Press F, et al. DIC score in pregnant women–a population based modification of the International Society on Thrombosis and Hemostasis score. PLoS One. 2014;9(4):e93240.

Downloads

Download data is not yet available.