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Vol. 12 No. 12 (2025)
International Multidisciplinary Journal for Research & Development

Articles

POLARIMETRIC ANALYSIS: PRINCIPLES, INSTRUMENTATION, AND APPLICATIONS IN PHARMACEUTICAL ANALYSIS

Published 2025-12-27

  • Obidov Dilmurod Xomidjon ugli

Obidov Dilmurod Xomidjon ugli
Asisstent at pharmaceutical department At Andijane State Medical Institute

Abstract

 Polarimetric analysis is a classical physicochemical analytical technique based on the measurement of optical rotation produced by optically active substances when plane-polarized light passes through them. This method plays a significant role in pharmaceutical, chemical, and biochemical analysis, particularly in the study of chiral compounds such as carbohydrates, amino acids, alkaloids, and certain active pharmaceutical ingredients. Due to its simplicity, non-destructive nature, and relatively high reproducibility, polarimetry is widely applied in routine quality control and raw material testing. This article presents an in-depth discussion of the theoretical background of polarimetry, the construction and operation of polarimetric instruments, analytical procedures, and the major applications, advantages, and limitations of the method in pharmaceutical analysis.

Keywords

Polarimetry; Optical rotation; Chiral compounds; Pharmaceutical analysis; Quality control

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References

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