POLARIMETRIC ANALYSIS: PRINCIPLES, INSTRUMENTATION, AND APPLICATIONS IN PHARMACEUTICAL ANALYSIS

Authors

Obidov Dilmurod Xomidjon ugli Asisstent at pharmaceutical department At Andijane State Medical Institute

Keywords:

Polarimetry; Optical rotation; Chiral compounds; Pharmaceutical analysis; Quality control

Abstract

Polarimetric analysis is a classical physicochemical analytical technique based on the measurement of optical rotation produced by optically active substances when plane-polarized light passes through them. This method plays a significant role in pharmaceutical, chemical, and biochemical analysis, particularly in the study of chiral compounds such as carbohydrates, amino acids, alkaloids, and certain active pharmaceutical ingredients. Due to its simplicity, non-destructive nature, and relatively high reproducibility, polarimetry is widely applied in routine quality control and raw material testing. This article presents an in-depth discussion of the theoretical background of polarimetry, the construction and operation of polarimetric instruments, analytical procedures, and the major applications, advantages, and limitations of the method in pharmaceutical analysis.

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References

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Published

2025-12-27

How to Cite

Obidov Dilmurod Xomidjon ugli. (2025). POLARIMETRIC ANALYSIS: PRINCIPLES, INSTRUMENTATION, AND APPLICATIONS IN PHARMACEUTICAL ANALYSIS. International Multidisciplinary Journal for Research & Development, 12(12), 1258–1260. Retrieved from https://www.ijmrd.in/index.php/imjrd/article/view/4564