Skip to main navigation menu Skip to main content Skip to site footer

ATHEROSCLEROSIS

Abstract

Atherosclerosis is a chronic and progressive cardiovascular disease characterized by the accumulation of lipids, cholesterol, calcium, and connective tissue elements within the arterial wall, resulting in the formation of atherosclerotic plaques. This pathological process leads to narrowing and reduced elasticity of blood vessels, impairing tissue perfusion. Atherosclerosis is the leading cause of coronary heart disease, myocardial infarction, stroke, and peripheral arterial disease. Major risk factors include dyslipidemia, arterial hypertension, smoking, diabetes mellitus, obesity, physical inactivity, and genetic predisposition. Early diagnosis, adherence to a healthy lifestyle, and comprehensive preventive strategies play a crucial role in reducing cardiovascular complications. Modern management of atherosclerosis involves pharmacological therapy (such as statins and antiplatelet agents) as well as invasive interventions when necessary [1,2].

Keywords

Atherosclerosis, cardiovascular diseases, atherosclerotic plaque, cholesterol, risk factors, prevention.

PDF

References

  1. Bekbossynova M, Saliev T, Ivanova-Razumova T, Andossova S, Kali A, Myrzakhmetova G. Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis. J Clin Med. 2025;14(7):2352. doi:10.3390/jcm14072352 — Review of novel risk factors including inflammation and microbiota in atherosclerosis.
  2. StatPearls. Atherosclerosis. NCBI Bookshelf. Updated review of etiology, pathogenesis, risk factors, and management of atherosclerotic cardiovascular disease.
  3. Waksman R, Merdler I, Case BC, Waksman O, Porto I. Targeting inflammation in atherosclerosis: overview, strategy and directions. Eur J Intern Med. 2024;20(1):32-44. Review on inflammation’s role and therapeutic strategies.
  4. TasouliDrakou V, Ogurek I, Shaikh T, Ringor M, DiCaro MV, Lei K. Atherosclerosis: A Comprehensive Review of Molecular Factors and Mechanisms. Int J Mol Sci. 2025;26(3):1364. Comprehensive molecular overview.
  5. Malekmohammad K, Bezsonov EE, RafieianKopaei M. Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms. Front Cardiovasc Med. 2021;8:707529. Insight into lipidinflammatory interplay.
  6. Bugger H, Zirlik A. Antiinflammatory Strategies in Atherosclerosis. Hamostaseologie. 2021;41(06):433442. Review on inflammation pathways and therapeutic options.
  7. Chaulin AM, Grigoryeva YV, Duplyakov DV. Modern Views about the Pathophysiology of Atherosclerosis: Role of Impaired Lipid Metabolism and Endothelial Dysfunction. Med Nauki Kuzb. 2025. Literature review on key pathogenic mechanisms.
  8. Sergienko IV, Ansheles AA. Pathogenesis, Diagnosis and Treatment of Atherosclerosis: Practical Aspects. Cardiol Vestnik. 2021;16(1):6472. Practical aspects overview.
  9. — Atherosclerosis and inflammation: current therapeutic strategies (Zubareva MY, Sergienko IV). Consilium Medicum 2024;26(1):3139. Review of immune mechanisms and inflammation in atherosclerosis.
  10. — Atherosclerosis. Wikipedia article summarizing pathogenesis, risk factors, clinical significance, and complications. (Use for general background definitions).

Downloads

Download data is not yet available.