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Vol. 13 No. 02 (2026)
International Multidisciplinary Journal for Research & Development

Articles

PROGNOSTIC SIGNIFICANCE OF CYTOKINE PROFILE AND NEUROIMAGING MARKERS IN THE PROGRESSION OF PARKINSON’S DISEASE

Published 2026-02-21

  • E.I. Abduqodirov, S.O. Inoyatova, M.U. Karimova, M.A. Maxamadxodjayeva, Q.K. Boboyev, N.A. Oqiljonova, Sh.Kh. Babakulov, F.O. Tuxliyeva.

E.I. Abduqodirov, S.O. Inoyatova, M.U. Karimova, M.A. Maxamadxodjayeva, Q.K. Boboyev, N.A. Oqiljonova, Sh.Kh. Babakulov, F.O. Tuxliyeva.
Tashkent State Medical University

Abstract

This scientific study analyzed 175 individuals, including 155 patients diagnosed with Parkinson's disease and 20 healthy controls, focusing on clinical subtypes (tremor-dominant, akinetic-rigid, and mixed forms). The research evaluated immunological (IL-1β, IL-6, TNF-α, IL-10), psychological (HADS, MMSE, VFT), and neurovisual (MRI) parameters. Results demonstrated significant differences in cytokine levels and cognitive-emotional status across subtypes. The findings underline the importance of a multidisciplinary approach to the diagnosis, classification, and personalized management of Parkinson’s disease.

Keywords

Parkinson’s disease, clinical subtypes, cytokines, UPDRS, MRI, psychological tests, immunological changes, neuroimaging.

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References

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