Skip to main navigation menu Skip to main content Skip to site footer

Vol. 13 No. 4 (2026)
International Multidisciplinary Journal for Research & Development

Articles

COMPARATIVE CHARACTERISTICS OF MODERN ENZYMES USED IN THE LOCAL TREATMENT OF FACIAL FURUNCLES IN CHILDREN

Published 2026-04-23

  • Ikramov Gayrat Alimovich , Abdikaimova Dilobar Vakhidjanovna, Abdukahorov Abdukahor Komil ugli , Narziev Mirshod Amirilloevich

Ikramov Gayrat Alimovich , Abdikaimova Dilobar Vakhidjanovna, Abdukahorov Abdukahor Komil ugli , Narziev Mirshod Amirilloevich
Tashkent State Medical University, EMU University

Abstract

The relevance of facial furuncles in pediatric practice is inseparably linked to the unique anatomical characteristics of the child’s body. According to the fundamental studies by Gubin (2018) and Paller (2022), the facial skin in children is significantly thinner than in adults, while the basal layer is characterized by high permeability. Traditionally, Staphylococcus aureus has been considered the principal causative agent of furunculosis. However, recent studies indexed in Scopus and PubMed (Shah, 2023; Smijs, 2022) have fundamentally changed the understanding of the biology of this process. It is biofilms that represent the main reason for the ineffectiveness of standard treatment in children.

Keywords

Physical barrier: the biofilm matrix slows down the diffusion of antibiotics. For example, aminoglycosides bind to matrix components and become inactivated before reaching the deeper layers.

PDF

References

  1. Berezhnova T.A., et al. Use of drug therapy in the treatment of abscesses and phlegmons of the face and neck. Scientific and Medical Bulletin of the Central Chernozem Region. 2024;25(2):29–34.
  2. Borodulina I.I., Petrova T.V. Use of immobilized trypsin in the comprehensive treatment of abscessing facial furuncle. Current Issues of Oral and Maxillofacial Surgery and Dentistry. 2022:213–219.
  3. Vakulenko E.N. Gender and seasonal characteristics of the course of maxillofacial phlegmons. Ukrainian Dental Almanac. 2015;(1).
  4. Glukhov A.A., et al. Personalized local treatment of chronic non-healing wounds. Outpatient Surgery. 2023;20(2):80–87.
  5. Iordanishvili A., et al., eds. Diseases, Injuries, and Tumors of the Maxillofacial Region. LitRes; 2015.
  6. Kabanova A.A., Tserkovsky A.L. Analysis of the use of antibacterial therapy in infectious and inflammatory diseases of the maxillofacial region and neck in the Republic of Belarus. Vestnik VGMU. 2019;(3).
  7. Kalinina O.Yu., Gaiko S.N., Usanova G.U. Analysis of treatment outcomes in patients with abscesses and phlegmons of the maxillofacial region. Bulletin of Clinical Hospital No. 51. 2016;7(2).
  8. Nikolsky V.Yu., Imbryakov K.V. Furuncles and carbuncles of the face. Russian Dental Journal. 2013;(5):52–56.
  9. Ostrovsky O.V., et al. The antioxidant Mexidol in the comprehensive treatment of facial furuncle. Journal of Scientific Publications of Postgraduate and Doctoral Students. 2011;(12):88–92.
  10. Ostrovsky O.V., et al. The state of prooxidant-antioxidant relationships in patients with facial furuncle during comprehensive treatment. Modern Problems of Science and Education. 2012;(1):4–4.
  11. Petrova T.V., Borodulina I.I., Chernegov V.V. Use of the sterile gauze dressing Proteox-TM in the comprehensive treatment of abscessing facial furuncle. Vrach. 2022;33(8):75–80.
  12. Tsarev S.V., et al. Use of the drug “Longidaza” in the treatment of polypous rhinosinusitis. Russian Allergology Journal. 2007;(3):63–69.

Downloads

Download data is not yet available.