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Vol. 13 No. 5 (2026)
International Multidisciplinary Journal for Research & Development

Articles

CHANGES IN THE IMMUNE SYSTEM IN DISEASES OF BACTERIAL ETIOLOGY AND MEASURES TO PREVENT AND ELIMINATE THE CHANGES THAT OCCUR

Published 2026-05-14

  • Nigora Sabitovna Gafurova, Nigina Talat kizi Ilyosboeva

Nigora Sabitovna Gafurova, Nigina Talat kizi Ilyosboeva
Senior Lecturer of the Department of Allergology, Clinical Immunology, and Microbiology at Tashkent State Medical University, Student of the Faculty of 2nd Pediatrics and Medical Biology, Tashkent State Medical University, Group 203

Abstract

The development and operation of the mammalian immune system and the commensal microbiota interact in a variety of ways in both homeostasis and illness. While the immune system coordinates the preservation of important aspects of host-microbe symbiosis, the microbiome plays crucial roles in the training and development of significant components of the host's innate and adaptive immune system. Imbalances in microbiota-immunity interactions under specific environmental conditions are thought to play a role in the pathophysiology of numerous immune-mediated illnesses in a genetically predisposed host. Here, we go over the characteristics of microbiome-immunity crosstalk and how it affects both health and illness. We also give examples of the molecular processes that control these interactions in the intestine and other extra-intestinal organs. We discuss how these insights may be applied to the future development of microbiome-targeted therapeutic interventions and highlight some of the current knowledge, obstacles, and limitations in obtaining causal understanding of host immune-microbiome interactions and their impact on immune-mediated diseases. As a result, numerous immune system disorders have been thoroughly examined at different stages of a person's life, along with their dependence on internal and external factors of various kinds, their detailed phenomenological characteristics, the impact of various diseases on the development of immune system disorders, and many other significant aspects of this issue.

Keywords

immunological reactivity, immunostimulation, immunosuppression, immune disease risk factors, immunoregulation.

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