CLASSIFICATION OF BIOLOGICAL FACTORS OF ORIGIN AUTOIMMUNE POLYGLANDULAR SYNDROME

Abstract

 Autoimmune polyglandular syndrome is an endocrinopathy of autoimmune origin that occurs with simultaneous primary multiple lesions of the endocrine glands and other organs. In autoimmune polyglandular syndrome type 1, there is adrenal insufficiency, candidiasis of the skin and mucous membranes, hypoparathyroidism; autoimmune polyglandular syndrome type 2 occurs with the development of adrenal insufficiency, hyper - or hypothyroidism, insulin-dependent diabetes mellitus, primary hypogonadism, myasthenia gravis, steatorrhea, and other disorders. Diagnostics includes determination of a complex of laboratory parameters (biochemical analysis, blood and urine hormones), ultrasound and CT of the adrenal glands, ultrasound of the thyroid gland. Treatment of autoimmune polyglandular syndrome requires hormone replacement therapy (corticosteroids and mineralocorticoids, L-thyroxine).