THE INCREASE OF ANTIBIOTIC RESISTANCE: EPIDEMIOLOGICAL ANALYSIS
Abstract
This article presents an analysis of the global and regional epidemiology of antimicrobial resistance (AMR). Findings indicate that rising bacterial resistance to antibiotics diminishes treatment efficacy, increases the economic burden on healthcare systems, and contributes to higher mortality rates. Using data from WHO and GLASS surveillance systems, the study assessed regional prevalence of resistant bacterial strains, key pathogens, and their resistance profiles. The results highlight that inappropriate antibiotic use, over-the-counter access, inadequate sanitation, limited diagnostic capacity, and insufficient preventive measures are primary factors driving AMR. Effective strategies for mitigation include antibiotic stewardship programs, implementation of the “One Health” approach, robust infection control systems, and continuous monitoring. The article offers both theoretical and practical recommendations for improving infection management and combating antimicrobial resistance.
Keywords
antibiotic resistance, infection prevention, epidemiology, rational use of antibiotics, AMR monitoring, antibiotic stewardship, One Health.
References
- Albukhari, A. F. (2022). Assessing drivers of antimicrobial resistance: A systematic review. International Journal of Laboratory & Pharmaceutical Technology, 11(2), 45–58.
- Centers for Disease Control and Prevention (CDC). (2023). Antibiotic Resistance Threats in the United States. Atlanta, GA.
- European Centre for Disease Prevention and Control (ECDC). (2024). Surveillance of antimicrobial resistance in Europe 2024. Stockholm: ECDC.
- GBD 2021 Antimicrobial Resistance Collaborators. (2023). Global burden of antimicrobial resistance, 1990–2021, and projections to 2050. Lancet Global Health.
- Guardabassi, L., Jensen, L. B., & Kruse, H. (2010). Guide to Antimicrobial Use in Animals. Wiley-Blackwell.
- Hernández-Navarro, L., Distefano, K., & Mobilia, M. (2024). Eco-evolutionary modelling of antimicrobial resistance. Mathematical Biosciences, 368, 108098.
- Murray, C. J. L., Ikuta, K. S., Sharara, F., Swetschinski, L., et al. (2022). Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet, 399(10325), 629–655.
- Swetschinski, L., Bloom, D. E., & Murray, C. J. L. (2020). Antimicrobial resistance drivers and burden: systematic review and analysis. Journal of Global Health, 10(1), 010405.
- World Health Organization (WHO). (2023). Global Action Plan on Antimicrobial Resistance: Progress Report. Geneva: WHO.
- World Health Organization (WHO). (2025). Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report. Geneva: WHO.
- Abdullayev, U. N., & Sharipov, F. I. (2020). Mikrobiologiyada rezistent shtammlarni aniqlashning zamonaviy usullari. Toshkent Tibbiyot Akademiyasi Ilmiy Axborotnomasi, 7(3), 58–66.
- Ismoilova, G. T., & Qodirov, B. O. (2023). Nozokomial infeksiyalar va ularning antibiotiklarga chidamlilik darajasi. Respublika Epidemiologiya Markazi Axborotnomasi, 12(1), 27–34.
- Karimova, S. R. (2024). Bir sog‘liq (One Health) yondashuvi va O‘zbekistonda AMR monitoringi. Veterinariya va Oziq-ovqat Xavfsizligi Jurnali, 5(1), 10–18.
- To‘xtasinov, S. R., Raximova, M. S., & Xolmirzaev, A. O. (2022). O‘zbekiston sharoitida antibiotiklarga rezistentlikning epidemiologik tahlili. Tibbiyot va Biotibbiyot Jurnali, 3(2), 15–25.
- Tursunov, M. K., & Norqulova, D. Sh. (2023). Antibiotiklardan noto‘g‘ri foydalanishning ijtimoiy omillari. Sog‘liqni Saqlash va Jamiyat, 2(2), 33–41.
- Yusupova, N. K., & Mamatqulov, R. B. (2021). Klinik amaliyotda antibiotiklarni oqilona qo‘llash: muammolar va yechimlar. O‘zbek Tibbiyoti Jurnali, 98(4), 45–52.