MOLECULAR AND BIOPHYSICAL BASIS OF MECHANOTRANSDUCTION IN ENDOTHELIAL CELLS

Abstract

This study investigates the molecular and biophysical mechanisms of mechanotransduction in endothelial cells, with a focus on how physical forces such as shear stress and cyclic stretch are converted into biochemical signals. Laboratory simulations and computer-based models were employed to demonstrate the role of mechanosensitive ion channels, cytoskeletal dynamics, and membrane-associated signaling complexes in endothelial mechanotransduction. The experiments highlighted how changes in membrane tension, ion fluxes, and cytoskeletal remodeling contribute to vascular function and homeostasis. The results provide insights into the bioelectrical and molecular foundations of endothelial responses to mechanical stimuli and underscore the importance of combining theoretical and experimental approaches in understanding vascular physiology.