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Vol. 13 No. 01 (2026)
International Multidisciplinary Journal for Research & Development

Articles

FORMULATION AND EVALUATION OF NANOEMULSION-BASED PHARMACEUTICAL PRODUCTS

Published 2026-01-16

  • Giyosova Habiba Isakjonovna

Giyosova Habiba Isakjonovna
Faculty of Pharmacy Department of Pharmaceutical Sciences–1 Assistant, Andijan State Medical Institute

Abstract

Nanoemulsion-based drug delivery systems have attracted considerable attention in modern pharmaceutical research due to their ability to enhance the solubility, stability, and bioavailability of poorly water-soluble drugs. The present study aimed to develop and evaluate a nanoemulsion formulation for a model lipophilic drug using high-energy emulsification techniques. Nanoemulsions were prepared using medium-chain triglycerides as the oil phase, Tween 80 as the surfactant, and polyethylene glycol 400 as the co-surfactant.

The prepared nanoemulsions were characterized in terms of droplet size, polydispersity index, zeta potential, drug content, encapsulation efficiency, in vitro drug release, and physical stability. The optimized formulation exhibited nanoscale droplet size with narrow size distribution, high encapsulation efficiency, and sufficient zeta potential values, indicating good physical stability. In vitro drug release studies demonstrated a biphasic release pattern with enhanced cumulative drug release compared to conventional drug suspensions. Stability studies confirmed that the nanoemulsion formulations remained physically stable under various storage conditions.

Overall, the results indicate that nanoemulsion-based formulations represent a promising and effective approach for improving the delivery of poorly water-soluble pharmaceutical compounds. Further in vivo studies are required to establish their clinical efficacy and safety.

Keywords

Nanoemulsion; drug delivery system; poorly water-soluble drugs; encapsulation efficiency; in vitro drug release; pharmaceutical formulation.

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