COMPARATIVE ANALYSIS AND SYSTEMATIZATION OF INTERNATIONAL AND NATIONAL CLINICAL GUIDELINES FOR THE MANAGEMENT OF POLYCYSTIC OVARY SYNDROME
Abstract
Background:
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder requiring evidence-based and standardized clinical management. Numerous international and national professional societies have developed clinical guidelines for PCOS; however, differences in diagnostic criteria and therapeutic approaches create challenges for clinical practice.
Objective:
To analyze and systematize current international and national clinical guidelines for the diagnosis and management of polycystic ovary syndrome, including recommendations from ESHRE, ACOG, and RARCh.
Methods:
An analytical review of official clinical guidelines published by leading international and national professional organizations was conducted. Diagnostic criteria, therapeutic strategies, and follow-up recommendations were systematically compared and structured according to clinical relevance.
Results:
Despite general consensus on core diagnostic principles, significant variability exists among guidelines regarding therapeutic prioritization, metabolic screening, and reproductive management. International guidelines emphasize individualized and multidisciplinary care, while national recommendations demonstrate adaptations to healthcare system capacities.
Conclusion:
Systematization of existing guidelines facilitates harmonization of clinical practice and supports the development of optimized, patient-centered management strategies for PCOS.
Keywords
Polycystic ovary syndrome; clinical guidelines; ESHRE; ACOG; RARCh; evidence-based medicine.
References
- Azziz R, Carmina E, Chen Z, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057.
- Teede HJ, Misso ML, Costello MF, et al. International evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod. 2018;33(9):1602–1618.
- Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016;31(12):2841–2855.
- March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010;25(2):544–551.
- Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106(1):6–15.
- Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod. 2012;27(10):3067–3073.
- Fauser BCJM, Tarlatzis BC, Rebar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome. Hum Reprod. 2012;27(1):14–24.
- Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2014;6:1–13.
- Ding T, Hardiman PJ, Petersen I, Wang FF, Qu F, Baio G. The prevalence of polycystic ovary syndrome in reproductive-aged women: a meta-analysis. Hum Reprod Update. 2017;23(6):697–713.
- Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–284.