CLINICAL POLYMORPHISM AND DIFFERENTIAL DIAGNOSIS OF ENTEROVIRUS INFECTIONS
Abstract
Among acute infectious diseases the pathologies caused by enteroviruses are distinguished by their extraordinary clinical polymorphism. This research article analyzes in detail the various clinical manifestations of enterovirus infections and explores the differential diagnostic criteria for distinguishing them from other etiologically similar diseases. The main focus is placed on the complex processes where a single virus serotype can cause many different syndromes and different serotypes can cause the same clinical condition. During the study the course of major clinical forms such as hand foot and mouth disease, herpangina, aseptic meningitis and myocarditis were examined. The results indicate that the correct application of modern molecular diagnostic methods such as the polymerase chain reaction and the early identification of specific clinical signs of the disease are of crucial importance in preventing unnecessary antibiotic therapy and providing timely adequate care to patients.
Keywords
enterovirus, clinical polymorphism, differential diagnosis, aseptic meningitis, coxsackievirus, hand foot and mouth disease.
References
- Pallansch M. A. and Roos R. I. (2001). Enteroviruses coxsackieviruses echoviruses and polioviruses. Fields Virology Volume 1 723-775.
- Repass G. L. Palmer W. C. and Stancampiano F. F. (2014). Hand foot and mouth disease identifying and managing an acute viral syndrome. Cleveland Clinic Journal of Medicine Volume 81 Issue 9 537-543.
- Solomon T. Lewthwaite P. Perera D. Cardosa M. J. McMinn P. and Ooi M. H. (2010). Virology epidemiology pathogenesis and control of enterovirus 71. The Lancet Infectious Diseases Volume 10 Issue 11 778-790.
- Yancy C. W. (2005). Myocarditis and enterovirus infection. New England Journal of Medicine Volume 353 Issue 14 1521-1524.
- Rotbart H. A. (2000). Viral meningitis. Seminars in Neurology Volume 20 Issue 3 277-292.
- Racaniello V. R. (2006). One hundred years of poliovirus pathogenesis. Virology Volume 344 Issue 1 9-16.
- Ramers C. Billman G. Garcia M. Braner D. and Sawyer M. H. (2000). Impact of a polymerase chain reaction assay for enterovirus on the management of infants. Journal of the American Medical Association Volume 283 Issue 20 2680-2685.
- Robinson C. C. Willis M. Meagher A. Gieseker K. E. and Wheelock H. (2002). Impact of rapid polymerase chain reaction results on management of pediatric patients with enteroviral meningitis. Pediatric Infectious Disease Journal Volume 21 Issue 4 283-286.
- Cherry J. D. (2004). Enteroviruses and parechoviruses. Textbook of Pediatric Infectious Diseases Volume 5 1984-2041.
- Messacar K. Schreiner T. L. and Dominguez S. R. (2016). Emergence of enterovirus D68 and acute flaccid myelitis. The Lancet Infectious Diseases Volume 16 Issue 5 516-518.