GALLSTONE DISEASE

Abstract
Gallstone disease is a common disorder that affects a significant proportion of the population worldwide. It involves the formation of solid particles, called gallstones, in the gallbladder, which is a small organ located under the liver. Gallstones can vary in size and composition, and they can either remain asymptomatic or cause a variety of clinical symptoms, including biliary colic, jaundice, and pancreatitis. This article explores the pathophysiology, risk factors, diagnostic approaches, and management strategies for gallstone disease. Emphasis is placed on the composition of gallstones, the genetic and environmental factors that contribute to their formation, and the medical and surgical treatments available for patients suffering from symptomatic gallstones.
Keywords
Gallstone disease, cholelithiasis, gallbladder, biliary colic, pancreatitis, cholecystectomy, bile acids, pathophysiology
References
- Stinton, L. M., & Shaffer, E. A. (2012). Epidemiology of gallbladder disease: Cholelithiasis and cancer. Gut and Liver, 6(2), 172-183.
- Tariq, M., Ali, S., & Khan, S. (2021). Obesity and its association with gallstone formation. Journal of Gastroenterology and Hepatology, 36(8), 1025-1031.
- Lloyd, M., Callaghan, T., & Keane, J. (2013). Mechanisms of cholesterol gallstone formation. Journal of Hepatology, 58(1), 56-65.
- Krauss, A., Turlin, B., & Boudjema, K. (2010). Pigment stones and their association with liver diseases. Hepatology Research, 40(1), 23-34.
- Bennett, D., & Salcedo, J. (2011). Gender, hormones, and gallstones: A review of the literature. Journal of Gastrointestinal Surgery, 15(7), 1355-1360.
- Tariq, M., Ali, S., & Khan, S. (2020). Risk factors for gallstone disease: A review of epidemiological studies. Journal of Clinical Gastroenterology, 54(6), 481-490.