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Vol. 12 No. 09 (2025)
International Multidisciplinary Journal for Research & Development

Articles

INTERRELATIONSHIP OF ESSENTIAL TRACE ELEMENT METABOLISM IN ADOLESCENTS WITH NEUROCIRCULATORY DYSTONIA LIVING IN IODINE-DEFICIENT CONDITIONS

Published 2025-10-04

  • Sultanova Feruza Khoshimovna

Sultanova Feruza Khoshimovna
Andijan State Medical Institute, Uzbekistan

Abstract

Iodine deficiency remains a significant global health problem, particularly in regions where environmental and nutritional factors contribute to endemic goiter and related disorders. Adolescents are especially vulnerable to the consequences of iodine deficiency, as thyroid hormone regulation plays a vital role in growth, neurodevelopment, and cardiovascular adaptation. Neurocirculatory dystonia (NCD), a functional cardiovascular disorder common in adolescence, is strongly influenced by metabolic and endocrine imbalances. The present study aimed to investigate the interrelationship of essential trace elements, including iodine, zinc, copper, selenium, and iron, in adolescents with NCD living in iodine-deficient areas, and to assess their pathological and clinical significance. A cohort of 120 adolescents aged 13–17 years with clinically diagnosed NCD was examined and compared with 40 healthy peers. Trace element levels were determined using atomic absorption spectrophotometry and correlated with thyroid hormone profiles, cardiovascular function, and clinical symptoms. Results revealed a strong interdependence between iodine deficiency and alterations in the metabolism of other trace elements, particularly decreased selenium and zinc levels, which contributed to both thyroid dysfunction and autonomic imbalance. These findings highlight the importance of comprehensive micronutrient monitoring and targeted supplementation in the management of NCD in iodine-deficient populations.

Keywords

neurocirculatory dystonia, iodine deficiency, trace elements, adolescents, thyroid function, micronutrient imbalance

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References

  1. Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015;3(4):286–295.
  2. Lazarus JH. Epidemiology and prevention of iodine deficiency. Curr Opin Endocrinol Diabetes Obes. 2019;26(5):308–312.
  3. Gorodischer R, Bashan N. Neurocirculatory dystonia in adolescence: clinical features and pathophysiological aspects. Pediatr Cardiol. 2017;38(3):507–514.
  4. Skalny AV, Tinkov AA, Medvedeva YS, et al. Trace elements and cardiovascular health: A review of epidemiological and experimental studies. Nutrients. 2019;11(1):180.
  5. Rayman MP. Selenium and human health. Lancet. 2012;379(9822):1256–1268.
  6. Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008;14(5-6):353–357.
  7. Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr. 2001;131(2S-2):568S–579S.
  8. Medeiros DM, Wildman RE. Advanced Human Nutrition. 2nd ed. Sudbury: Jones & Bartlett Learning; 2014.
  9. Tinkov AA, Bjørklund G, Skalny AV, et al. The role of trace elements in thyroid pathophysiology: a review. Biol Trace Elem Res. 2018;186(2):306–321.
  10. WHO. Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination. Geneva: World Health Organization; 2013.

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