THE ROLE OF INTERLEUKIN-10 AND TUMOR NECROSIS FACTOR-ALPHA IN CHRONIC RHEUMATIC HEART DISEASE
Abstract
Chronic rheumatic heart disease (CRHD) remains a significant cause of acquired heart defects in children and adolescents. Immune dysregulation is central to disease progression. Cytokines, especially interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha), are key modulators of inflammation. This study investigates serum IL-10 and TNF-alpha levels as diagnostic and prognostic markers in pediatric CRHD.Keywords
chronic rheumatic heart disease, interleukin-10, TNF-alpha, cytokines, inflammation, children
References
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