INVESTIGATION OF THE HEPATOPROTECTIVE EFFECT OF ANACARDIUM IN AN ETHANOL-INDUCED HEPATITIS MODEL

Abstract

This article presents the results of experimental studies on the hepatoprotective effects of the plant-derived polyphenolic compound anacardine in models of acute ethanol-induced liver injury. The relevance of the research lies in the limited availability and efficacy of local hepatoprotective drugs in the global pharmaceutical market, highlighting the need for effective, low-toxicity, and affordable plant-based alternatives. The study was conducted in accordance with international ethical standards using Wistar rats, and liver injury was induced using 33% ethanol. Anacardine was administered orally and intraperitoneally in various doses. The therapeutic efficacy was assessed by biochemical markers such as ALT, total protein, lipid peroxidation products (DCs and TBARS), and hepatoprotection coefficients. The results demonstrated that an oral dose of 100 mg/kg and an intraperitoneal dose of 5 mg/kg of anacardine showed the most significant improvement in liver function indicators, suggesting optimal hepatoprotective effects. Compared to standard treatment with Karsil, anacardine exhibited comparable or even superior results in some parameters. The findings support the potential use of anacardine as a natural hepatoprotective agent in liver injury associated with alcohol toxicity.