THE STUDY OF THE HEPATOPROTECTIVE EFFECT OF ANACARDIC ACID IN A CARBON TETRACHLORIDE-INDUCED HEPATITIS MODEL

Abstract

This study explores the hepatoprotective effects of anacardic acid, a polyphenolic compound, in a rat model of acute liver injury induced by carbon tetrachloride (CCl₄). Given the increasing exposure to hepatotoxic xenobiotics from household, industrial, and agricultural chemicals, the development of effective and multi-targeted hepatoprotective agents is critical. The experiment was conducted in compliance with international animal ethics guidelines using Wistar rats. The research assessed various doses of anacardic acid administered both orally and intraperitoneally. Biochemical markers such as ALT, total protein, diene conjugates, and malondialdehyde (MDA) levels were measured to evaluate liver function and oxidative stress. The findings demonstrated that anacardic acid, particularly at a dose of 5 mg/kg administered intraperitoneally, significantly mitigated liver damage, restored biochemical parameters, and showed comparable efficacy to the standard hepatoprotective agent Karsil. These results suggest that anacardic acid possesses promising hepatoprotective properties and warrants further investigation as a potential therapeutic agent for hepatobiliary pathologies.