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Vol. 12 No. 11 (2025)
International Multidisciplinary Journal for Research & Development

Articles

THE ROLE OF TUMOR NECROSIS FACTOR ALPHA (TNF-Α) IN CHRONIC RHEUMATIC HEART DISEASE IN CHILDREN

Published 2025-11-15

  • Bobojonov Khurshid Jumaniyozovich

Bobojonov Khurshid Jumaniyozovich
Lecturer at the Department of Pre-Clinical Sciences Asia International University

Abstract

Chronic rheumatic heart disease (CRHD) remains one of the most common causes of acquired heart defects in children, especially in developing countries. Tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, plays a crucial role in mediating immune and inflammatory responses in rheumatic fever and its chronic outcomes. Elevated TNF-α levels reflect the degree of myocardial and valvular inflammation, which contributes to the progression of cardiac lesions. Assessing TNF-α concentrations in the blood may improve diagnosis, monitoring, and therapeutic management of CRHD.

Keywords

chronic rheumatic heart disease, TNF-α, cytokines, inflammation, children, biomarkers

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References

  1. WHO. Rheumatic Fever and Rheumatic Heart Disease: Technical Report. Geneva, 2021.
  2. Braunwald E. Heart Disease: Textbook of Cardiovascular Medicine. 12th ed., 2021.
  3. Shabalov N.P. Pediatrics: textbook. St. Petersburg: SpetsLit, 2020.
  4. Gupta S., et al. Role of TNF-α in the pathogenesis of rheumatic carditis. J Clin Immunol, 2022; 14(2): 135–143.
  5. Kumar A., et al. Cytokine markers in rheumatic heart disease. Int J Cardiol Res, 2023; 19(3): 201–210 Pediatrics: a textbook for medical universities / edited by N. P.

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