MODERN CONCEPTIONS OF THE PROPERTIES OF CLINICAL PHARMACOLOGY

Abstract

Clinical pharmacology is an interdisciplinary field that investigates the effects of medicinal substances on the human body, considering molecular, biochemical, physiological, clinical, and pharmacogenetic factors. Over the past decades, this discipline has undergone significant evolution: methods for evaluating drug efficacy and safety have expanded, personalized approaches have been implemented, pharmacogenomics and therapeutic drug monitoring (TDM) have advanced, and principles of rational pharmacotherapy have been refined. This article summarizes current views on the key properties of clinical pharmacology, including pharmacokinetics, pharmacodynamics, drug interactions, therapy safety, pharmacoepidemiology, and pharmacoeconomics. Emerging directions, its role in evidence-based medicine, and the importance of integrating personalized medicine are also discussed.