BIOPHYSICAL MECHANISMS OF NEURONAL ELECTRICAL SIGNALING AND EPILEPTOGENESIS: INSIGHTS FROM EXPERIMENTAL STUDIES

Abstract

This study investigates the biophysical basis of neuronal electrical signaling and the mechanisms underlying epileptogenesis, drawing upon classical and contemporary sources, including Moore & Persaud’s 'The Developing Human: Clinically Oriented Embryology' (11th ed., 2019) and Wengert & Cohen’s 'The Role of the Persistent Sodium Current in Epilepsy' (2021). Experimental analyses were conducted at the Department of Physiology, Tashkent State Medical University, under controlled laboratory conditions, aiming to bridge theoretical knowledge with practical observations. The article highlights the role of ionic currents, particularly persistent sodium and potassium conductances, in shaping neuronal excitability and initiating hyper-synchronous activity leading to epileptic seizures.